SimInSitu Project: Advancing Dissemination and Expanding Scientific Impact

As the H2020 SimInSitu project approaches the end of the fourth year project, we are proud to reflect on our dissemination achievements so far. The project has already resulted in 10 peer-reviewed publications, highlighting significant advancements in patient-specific computational modeling, tissue-engineered heart valve, and growth and remodeling. These contributions underscore SimInSitu’s commitment to developing credible in-silico platforms for biomedical device evaluation.

Looking ahead to the 2025, we are excited to build upon this strong foundation and further expand our scientific impact. Upcoming publications will focus on key areas of innovation, including endogenous tissue regeneration, fluid-structure interaction (FSI) modeling, and verification, validation, and uncertainty quantification (VVUQ) assessments in accordance with ASME V&V 40 guidelines. These studies will not only enhance the credibility of computational models but also support their application in regulatory and clinical workflows.

By integrating advanced computational techniques with rigorous validation frameworks, SimInSitu continues to push the boundaries of biomedical engineering and regenerative medicine. Our work aims to accelerate the development of next-generation TEHVs, such as the biodegradable device by Xeltis, and set new standards for precision medicine and device testing.

We look forward to sharing more groundbreaking results in the coming year as we advance toward SimInSitu’s ultimate goal of establishing a robust platform for patient-specific modeling and simulation. Stay connected for updates as we continue to innovate at the intersection of engineering, biology, and medicine.